Collagen has become one of the biggest categories in the supplement industry — but does it actually work, or is it mostly marketing? A landmark 2026 review pulling together 113 clinical trials and nearly 8,000 participants finally gives a clear, evidence-based answer for several key uses. What Is Collagen? Collagen is the most abundant protein in the human body, providing structure to skin, bones, tendons, ligaments, and cartilage. Collagen is made up of amino acids including glycine, proline, and hydroxyproline , arranged in a triple-helix structure that gives connective tissue its strength. 💡 Did You Know? Natural collagen production declines with age, which is a major reason interest in collagen supplements has grown alongside concerns about skin aging and joint health. What the Largest Review to Date Actually Found The 2026 umbrella review, published in Aesthetic Surgery Journal Open Forum, combined 16 systematic reviews and 113 randomized controlled trials. It found: ...
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